van Wijk, BC;
Beudel, M;
Jha, A;
Oswal, A;
Foltynie, T;
Hariz, MI;
Limousin, P;
... Litvak, V; + view all
(2016)
Subthalamic nucleus phase-amplitude coupling correlates with motor impairment in Parkinson's disease.
Clinical Neurophysiology
, 127
(4)
pp. 2010-2019.
10.1016/j.clinph.2016.01.015.
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Abstract
OBJECTIVE: High-amplitude beta band oscillations within the subthalamic nucleus are frequently associated with Parkinson's disease but it is unclear how they might lead to motor impairments. Here we investigate a likely pathological coupling between the phase of beta band oscillations and the amplitude of high-frequency oscillations around 300Hz. METHODS: We analysed an extensive data set comprising resting-state recordings obtained from deep brain stimulation electrodes in 33 patients before and/or after taking dopaminergic medication. We correlated mean values of spectral power and phase-amplitude coupling with severity of hemibody bradykinesia/rigidity. In addition, we used simultaneously recorded magnetoencephalography to look at functional interactions between the subthalamic nucleus and ipsilateral motor cortex. RESULTS: Beta band power and phase-amplitude coupling within the subthalamic nucleus correlated positively with severity of motor impairment. This effect was more pronounced within the low-beta range, whilst coherence between subthalamic nucleus and motor cortex was dominant in the high-beta range. CONCLUSIONS: We speculate that the beta band might impede pro-kinetic high-frequency activity patterns when phase-amplitude coupling is prominent. Furthermore, results provide evidence for a functional subdivision of the beta band into low and high frequencies. SIGNIFICANCE: Our findings contribute to the interpretation of oscillatory activity within the cortico-basal ganglia circuit.
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