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Homoeologs: What Are They and How Do We Infer Them?

Glover, NM; Redestig, H; Dessimoz, C; (2016) Homoeologs: What Are They and How Do We Infer Them? Trends in Plant Science , 21 (7) pp. 609-621. 10.1016/j.tplants.2016.02.005. Green open access

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Abstract

The evolutionary history of nearly all flowering plants includes a polyploidization event. Homologous genes resulting from allopolyploidy are commonly referred to as 'homoeologs', although this term has not always been used precisely or consistently in the literature. With several allopolyploid genome sequencing projects under way, there is a pressing need for computational methods for homoeology inference. Here we review the definition of homoeology in historical and modern contexts and propose a precise and testable definition highlighting the connection between homoeologs and orthologs. In the second part, we survey experimental and computational methods of homoeolog inference, considering the strengths and limitations of each approach. Establishing a precise and evolutionarily meaningful definition of homoeology is essential for understanding the evolutionary consequences of polyploidization.

Type: Article
Title: Homoeologs: What Are They and How Do We Infer Them?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tplants.2016.02.005
Publisher version: http://dx.doi.org/10.1016/j.tplants.2016.02.005
Language: English
Additional information: Copyright © 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: homoeology, homology, polyploidy, positional homoeology
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: http://discovery.ucl.ac.uk/id/eprint/1478138
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