Bosma, LVAE and Kragt, JJ and Brieva, L and Khaleeli, Z and Montalban, X and Polman, CH and Thompson, AJ and Tintore, M and Uitdehaag, BMJ (2010) Progression on the Multiple Sclerosis Functional Composite in multiple sclerosis: what is the optimal cut-off for the three components? MULT SCLER , 16 (7) 862 - 867. 10.1177/1352458510370464.
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For the Timed 25-Foot Walk (T25FW) and 9-Hole Peg Test (9HPT), components of the Multiple Sclerosis Functional Composite (MSFC), cut-off points of 20% change have previously been defined as meaningful endpoints of functional decline. Recently, however, a 15% change of MSFC components was introduced. The objective of this study was to determine optimal cut-offs for all MSFC components to indicate clinical disease progression in a primary progressive (PP) multiple sclerosis (MS) population. T25FW, 9HPT and the Paced Auditory Serial Addition Test (PASAT) were performed in 161 patients with PPMS with a 2-year interval. Absolute and relative differences in test scores were calculated. For each cut-off point of relative change, proportions of patients who progressed (deterioration beyond cut-off value) and improved (improvement beyond cut-off value) were calculated. Further, we calculated the ratio of 'improved' versus 'progressed' patients. Line graphs were created indicating: percentage progressed patients, percentage improved patients, and ratio of improved versus progressed patients. The optimal cut-off was determined by searching the cutoff point with the lowest ratio of improved versus progressed patients, while at the same time capturing a substantial amount of progression. For both T25FW and 9HPT, the ratio between patients that improved and worsened clearly decreased between the cut-offs of 15% and 20%. For the PASAT, the ratio between patients improved and worsened was persistently poor. In conclusion, a cut-off of 20% for both T25FW and 9HPT has a better signal-to-noise ratio than lower values (e.g. 15%) and is therefore preferable for the assessment of disease progression. No satisfactory cut-off point for the PASAT could be determined.
|Title:||Progression on the Multiple Sclerosis Functional Composite in multiple sclerosis: what is the optimal cut-off for the three components?|
|Keywords:||9-Hole Peg Test, multiple sclerosis, Multiple Sclerosis Functional Composite, outcome measurement, Paced Auditory Serial Addition Test, primary progressive, Timed 25-Foot Walk, PLACEBO-CONTROLLED TRIAL, DOUBLE-BLIND, INTERFERON BETA-1A, OUTCOME MEASURE, RELIABLE CHANGE, CLINICAL-TRIAL, MS, MULTICENTER, DISABILITY, NATALIZUMAB|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Brain Sciences|
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