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Pathway analysis of whole exome sequence data provides further support for the involvement of histone modification in the aetiology of schizophrenia

Curtis, D; (2016) Pathway analysis of whole exome sequence data provides further support for the involvement of histone modification in the aetiology of schizophrenia. Psychiatric Genetics , 26 (5) pp. 223-227. 10.1097/YPG.0000000000000132. Green open access

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Abstract

Weighted burden pathway analysis was applied to whole exome sequence data for 2045 schizophrenic patients and 2045 controls. Overall, there was a statistically significant excess of pathways with more rare, functional variants in cases than in controls. Among the highest ranked were pathways relating to histone modification, as well as neuron differentiation and membrane and vesicle function. This bolsters the evidence from previous studies that histone modification pathways may be important in the aetiology of schizophrenia.

Type: Article
Title: Pathway analysis of whole exome sequence data provides further support for the involvement of histone modification in the aetiology of schizophrenia
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/YPG.0000000000000132
Publisher version: http://dx.doi.org/10.1097/YPG.0000000000000132
Language: English
Additional information: Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
Keywords: Schizophrenia; association; pathway analysis; histone modification
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: http://discovery.ucl.ac.uk/id/eprint/1476984
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