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Increased urinary free immunoglobulin light chain excretion in patients with multiple sclerosis

Dobson, R; Miller, RF; Palmer, HE; Feldmann, M; Thompson, EJ; Thompson, AJ; Miller, DH; (2010) Increased urinary free immunoglobulin light chain excretion in patients with multiple sclerosis. J NEUROIMMUNOL , 220 (1-2) 99 - 103. 10.1016/j.jneuroim.2010.01.012.

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Abstract

Background: Plasma and B cells are implicated in multiple sclerosis (MS) and produce free light chains (FLC) that are excreted in urine. Objective: To confirm that demyelinating diseases (DD) cause increased urinary FLCs.Method: Urinary FLC in 50 patients with DD were compared to 20 patients with posterior uveitis (PU), 19 with AIDS, 34 with rheumatoid arthritis (RA) and 19 normal controls (NC). Result: Subjects with DD, PU, RA and AIDS have higher urinary FLCs than NC (p <0.01). Urinary FLCs did not correlate with gadolinium-enhancing lesions on MRI.Conclusions: Urinary FLCs are raised in DD. Further studies are required to see if they correlate with disease activity. (C) 2010 Elsevier B.V. All rights reserved.

Type: Article
Title: Increased urinary free immunoglobulin light chain excretion in patients with multiple sclerosis
DOI: 10.1016/j.jneuroim.2010.01.012
Keywords: Urine, Nitrate, Nitrite, Rheumatoid arthritis, HIV-1, Posterior uvertrs, RHEUMATOID-ARTHRITIS, CEREBROSPINAL-FLUID, B-CELL, OLIGOCLONAL BANDS, AQUEOUS-HUMOR, MRI, DISEASE, PROTEINURIA, IMPAIRMENT, DISABILITY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health > Infection and Population Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Health Informatics
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Health Informatics > Clinical Epidemiology
URI: http://discovery.ucl.ac.uk/id/eprint/147697
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