UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines

Campbell, J; Ryan, CJ; Brough, R; Bajrami, I; Pemberton, HN; Chong, IY; Costa-Cabral, S; ... Lord, CJ; + view all (2016) Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines. Cell Reports , 14 (10) pp. 2490-2501. 10.1016/j.celrep.2016.02.023. Green open access

[img]
Preview
Text
Fenton_1-s2.0-S2211124716301267-main.pdf

Download (6MB) | Preview

Abstract

One approach to identifying cancer-specific vulnerabilities and therapeutic targets is to profile genetic dependencies in cancer cell lines. Here, we describe data from a series of siRNA screens that identify the kinase genetic dependencies in 117 cancer cell lines from ten cancer types. By integrating the siRNA screen data with molecular profiling data, including exome sequencing data, we show how vulnerabilities/genetic dependencies that are associated with mutations in specific cancer driver genes can be identified. By integrating additional data sets into this analysis, including protein-protein interaction data, we also demonstrate that the genetic dependencies associated with many cancer driver genes form dense connections on functional interaction networks. We demonstrate the utility of this resource by using it to predict the drug sensitivity of genetically or histologically defined subsets of tumor cell lines, including an increased sensitivity of osteosarcoma cell lines to FGFR inhibitors and SMAD4 mutant tumor cells to mitotic inhibitors.

Type: Article
Title: Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.celrep.2016.02.023
Publisher version: http://dx.doi.org/10.1016/j.celrep.2016.02.023
Language: English
Additional information: This is an open access article under the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/1476691
Downloads since deposit
95Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item