Jin, M;
Yu, DG;
Wang, X;
Geraldes, CF;
Williams, GR;
Bligh, SW;
(2016)
Electrospun Contrast Agent-Loaded Fibers for Colon-Targeted MRI.
Advanced Healthcare Materials
10.1002/adhm.201500872.
(In press).
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Abstract
Magnetic resonance imaging is a diagnostic tool used for detecting abnormal organs and tissues, often using Gd(III) complexes as contrast-enhancing agents. In this work, core-shell polymer fibers have been prepared using coaxial electrospinning, with the intent of delivering gadolinium (III) diethylenetriaminepentaacetate hydrate (Gd(DTPA)) selectively to the colon. The fibers comprise a poly(ethylene oxide) (PEO) core loaded with Gd(DTPA), and a Eudragit S100 shell. They are homogeneous, with distinct core-shell phases. The components in the fibers are dispersed in an amorphous fashion. The proton relaxivities of Gd(DTPA) are preserved after electrospinning. To permit easy visualization of the release of the active ingredient from the fibers, analogous materials are prepared loaded with the dye rhodamine B. Very little release is seen in a pH 1.0 buffer, while sustained release is seen at pH 7.4. The fibers thus have the potential to selectively deliver Gd(DTPA) to the colon. Mucoadhesion studies reveal there are strong adhesive forces between porcine colon mucosa and PEO from the core, and the dye-loaded fibers can be successfully used to image the porcine colon wall. The electrospun core-shell fibers prepared in this work can thus be developed as advanced functional materials for effective imaging of colonic abnormalities.
Type: | Article |
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Title: | Electrospun Contrast Agent-Loaded Fibers for Colon-Targeted MRI |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1002/adhm.201500872 |
Publisher version: | http://dx.doi.org/10.1002/adhm.201500872 |
Language: | English |
Additional information: | This is the peer reviewed version of the following article: Jin, M; Yu, DG; Wang, X; Geraldes, CF; Williams, GR; Bligh, SW; (2016) Electrospun Contrast Agent-Loaded Fibers for Colon-Targeted MRI. Advanced Healthcare Materials, which has been published in final form at http://dx.doi.org/10.1002/adhm.201500872. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Keywords: | Gd(III) complex, coaxial electrospinning, colon-targeted delivery, core-shell fibers, magnetic resonance imaging |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
URI: | https://discovery.ucl.ac.uk/id/eprint/1475708 |
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