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Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection

Mukherjee, UA; Ong, SB; Ong, SG; Hausenloy, DJ; (2015) Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection. Pharmacology and Therapeutics , 156 pp. 34-43. 10.1016/j.pharmthera.2015.10.005. Green open access

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Abstract

Ischemic heart disease (IHD) is the leading cause of death and disability worldwide. Therefore, novel therapeutic targets for protecting the heart against acute ischemia/reperfusion injury (IRI) are required to attenuate cardiomyocyte death, preserve myocardial function, and prevent the onset of heart failure. In this regard, a specific group of mitochondrial proteins, which have been linked to familial forms of Parkinson's disease (PD), may provide novel therapeutic targets for cardioprotection. In dopaminergic neurons of the substantia nigra, these PD proteins, which include Parkin, PINK1, DJ-1, LRRK2, and α-synuclein, play essential roles in preventing cell death-through maintaining normal mitochondrial function, protecting against oxidative stress, mediating mitophagy, and preventing apoptosis. These rare familial forms of PD may therefore provide important insights into the pathophysiology underlying mitochondrial dysfunction and the development of PD. Interestingly, these PD proteins are also present in the heart, but their role in myocardial health and disease is not clear. In this article, we review the role of these PD proteins in the heart and explore their potential as novel mitochondrial targets for cardioprotection.

Type: Article
Title: Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.pharmthera.2015.10.005
Publisher version: http://dx.doi.org/10.1016/j.pharmthera.2015.10.005
Language: English
Additional information: © 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Coronary heart disease, Parkinson’s disease, ischaemic preconditioning, mitochondria, myocardial ischaemia-reperfusion injury
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: http://discovery.ucl.ac.uk/id/eprint/1475349
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