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The history of the CATH structural classification of protein domains

Sillitoe, I; Dawson, N; Thornton, J; Orengo, C; (2015) The history of the CATH structural classification of protein domains. Biochimie , 119 pp. 209-217. 10.1016/j.biochi.2015.08.004. Green open access

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Abstract

This article presents a historical review of the protein structure classification database CATH. Together with the SCOP database, CATH remains comprehensive and reasonably up-to-date with the now more than 100,000 protein structures in the PDB. We review the expansion of the CATH and SCOP resources to capture predicted domain structures in the genome sequence data and to provide information on the likely functions of proteins mediated by their constituent domains. The establishment of comprehensive function annotation resources has also meant that domain families can be functionally annotated allowing insights into functional divergence and evolution within protein families.

Type: Article
Title: The history of the CATH structural classification of protein domains
Location: France
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.biochi.2015.08.004
Publisher version: http://dx.doi.org/10.1016/j.biochi.2015.08.004
Language: English
Additional information: © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Protein structure, Structure classification
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1474732
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