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Comparative proteomics of Acidithiobacillus ferrooxidans grown in the presence and absence of uranium

Dekker, L; Arsène-Ploetze, F; Santini, JM; (2016) Comparative proteomics of Acidithiobacillus ferrooxidans grown in the presence and absence of uranium. Research in Microbiology , 167 (3) pp. 234-239. 10.1016/j.resmic.2016.01.007. Green open access

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Abstract

Acidithiobacillus ferrooxidans is an acidophile that thrives in metal-contaminated environments and tolerates high levels of uranium. To gain a better understanding of the processes involved in U(VI) resistance, comparative proteomics was used. The proteome of A. ferrooxidans was grown in the presence and absence of 0.5 mM U(VI); expression of 17 proteins was upregulated and one was downregulated. Most proteins with increased expression are part of the general stress response or are involved in reactive oxygen species detoxification. Four novel proteins showed increased expression in the presence of U(VI) and may contribute to U(VI) resistance via thiol homoeostasis and U(VI) binding.

Type: Article
Title: Comparative proteomics of Acidithiobacillus ferrooxidans grown in the presence and absence of uranium
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.resmic.2016.01.007
Publisher version: http://dx.doi.org/10.1016/j.resmic.2016.01.007
Language: English
Additional information: © 2016 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Acidithiobacillus ferrooxidans, Acidophile, Proteome, Stress, Uranium resistance
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1474235
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