Ballantyne, C and Cushman, M and Psaty, B and Furberg, C and Khaw, KT and Sandhu, M and Oldgren, J and Rossi, GP and Maiolino, G and Cesari, M and Lenzini, L and James, SK and Rimm, E and Collins, R and Anderson, J and Koenig, W and Brenner, H and Rothenbacher, D and Berglund, G and Persson, M and Berger, P and Brilakis, E and McConnell, JP and Koenig, W and Sacco, R and Elkind, M and Talmud, P and Rimm, E and Cannon, CP and Packard, C and Cannon, CP and Barrett-Connor, E and Hofman, A and Kardys, I and Witteman, JCM and Criqui, M and Corsetti, JP and Rainwater, DL and Moss, AJ and Robins, S and Bloomfield, H and Collins, D and Packard, C and Ridker, P and Ballantyne, C and Cannon, CP and Collins, R and Criqui, M and Cushman, M and Danesh, J and Gu, D and Hofman, A and Nelson, JJ and Packard, C and Thompson, S and Zalewski, A and Danesh, J and Collins, R and Di Angelantonio, E and Kaptoge, S and Thompson, A and Thompson, S and Watson, S and Wood, A and Lp-PLA2 Studies Collaboration, (2007) Collaborative meta-analysis of individual participant data from observational studies of Lp-PLA(2) and cardiovascular diseases. EUR J CARDIOV PREV R , 14 (1) 3 - 11.
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Background A large number of observational epidemiological studies have reported generally positive associations' between circulating mass and activity levels of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) and the risk of cardiovascular diseases. Few studies have been large enough to provide reliable estimates in different circumstances, such as in different subgroups (e.g., by age group, sex, or smoking status) or at different Lp-PLA2 levels. Moreover, most published studies have related disease risk only to baseline values of Lp-PLA(2) markers (which can lead to substantial underestimation of any risk relationships because of within-person variability over time) and have used different approaches to adjustment for possible confounding factors.Objectives By combination of data from individual participants from all relevant observational studies in a systematic,meta-analysis, with correction for regression dilution (using available data on serial measurements of Lp-PLA(2)), the Lp-PLA(2) Studies Collaboration will aim to characterize more precisely than has previously been possible the strength and shape of the age and sex-specific associations of plasma Lp-PLA(2) with coronary heart disease (and, where data are sufficient with other vascular diseases, such as ischaemic stroke). It will also help to determine to what extent such associations are independent of possible confounding factors and to explore potential sources of heterogeneity among studies, such as those related to assay methods and study design. It is anticipated that the present collaboration will serve as a framework to investigate related questions on Lp-PLA(2) and cardiovascular outcomes.Methods A central database is being established containing data on circulating Lp-PLA(2) values, sex and other potential confounding factors, age at baseline Lp-PLA(2) Measurement, age at event or at last follow-up, major vascular morbidity and cause-specific mortality. Information about any repeat measurements of Lp-PLA2 and potential confounding factors has been sought to allow adjustment for possible confounding and correction for regression dilution. The analyses will involve age-specific regression models. Synthesis of the available observational studies of Lp-PLA(2) will yield information on a total of about 15 000 cardiovascular disease endpoints.
|Title:||Collaborative meta-analysis of individual participant data from observational studies of Lp-PLA(2) and cardiovascular diseases|
|Keywords:||meta-analysis, lipoprotein-associated phospholipase A(2), vascular disease, ACTIVATING-FACTOR-ACETYLHYDROLASE, LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE-A2, CORONARY-HEART-DISEASE, C-REACTIVE PROTEIN, MIDDLE-AGED MEN, MYOCARDIAL-INFARCTION, FOLLOW-UP, ATHEROSCLEROSIS RISK, ISCHEMIC-STROKE, ARTERY-DISEASE|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science|
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