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Molecular phylogenetics: principles and practice

Yang, Z; Rannala, B; (2012) Molecular phylogenetics: principles and practice. Nature Reviews Genetics , 13 (5) pp. 303-314. 10.1038/nrg3186. Green open access

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Abstract

Phylogenies are important for addressing various biological questions such as relationships among species or genes, the origin and spread of viral infection and the demographic changes and migration patterns of species. The advancement of sequencing technologies has taken phylogenetic analysis to a new height. Phylogenies have permeated nearly every branch of biology, and the plethora of phylogenetic methods and software packages that are now available may seem daunting to an experimental biologist. Here, we review the major methods of phylogenetic analysis, including parsimony, distance, likelihood and Bayesian methods. We discuss their strengths and weaknesses and provide guidance for their use.

Type: Article
Title: Molecular phylogenetics: principles and practice
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nrg3186
Publisher version: http://dx.doi.org/10.1038/nrg3186
Language: English
Additional information: Copyright © 2012 Macmillan Publishers Limited. All rights reserved.
Keywords: Base Sequence, Female, Humans, Male, Models, Biological, Models, Statistical, Molecular Sequence Data, Phylogeny, Software
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)
UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) > Genetics, Evolution and Environment
URI: http://discovery.ucl.ac.uk/id/eprint/1473673
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