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Relative efficacy of intravenous methylprednisolone and ACTH in the treatment of acute relapse in MS.

Thompson, AJ; Kennard, C; Swash, M; Summers, B; Yuill, GM; Shepherd, DI; Roche, S; (1989) Relative efficacy of intravenous methylprednisolone and ACTH in the treatment of acute relapse in MS. Neurology , 39 (7) 969 - 971.

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Abstract

To compare the efficacy of high-dose intravenous methylprednisolone with intramuscular ACTH in the treatment of acute relapse in multiple sclerosis, we undertook a double-blind, randomized, controlled study involving 61 patients. There was a marked improvement in both groups in the course of the study, but no difference between them in either the rate of recovery or the final outcome. High-dose IV methylprednisolone is a safe alternative to ACTH in the management of acute relapse in MS.

Type: Article
Title: Relative efficacy of intravenous methylprednisolone and ACTH in the treatment of acute relapse in MS.
Location: UNITED STATES
Language: English
Keywords: Acute Disease, Adrenocorticotropic Hormone, Adult, Clinical Trials as Topic, Female, Humans, Injections, Intramuscular, Injections, Intravenous, Male, Methylprednisolone, Multiple Sclerosis, Recurrence
UCL classification: UCL > School of Life and Medical Sciences > Faculty of Brain Sciences
URI: http://discovery.ucl.ac.uk/id/eprint/147302
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