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BIOCHEMICAL-CHANGES WITHIN A MULTIPLE-SCLEROSIS PLAQUE INVIVO

CADOUXHUDSON, TAD; KERMODE, A; RAJAGOPALAN, B; TAYLOR, D; THOMPSON, AJ; ORMEROD, IEC; ... RADDA, GK; + view all (1991) BIOCHEMICAL-CHANGES WITHIN A MULTIPLE-SCLEROSIS PLAQUE INVIVO. J NEUROL NEUROSUR PS , 54 (11) 1004 - 1006.

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Abstract

Magnetic resonance spectroscopy (MRS) was performed on a superficial part of the brain containing a large multiple sclerosis (MS) lesion. Reduced levels of phosphocreatine (PCr) relative to adenosine triphosphate (ATP) were found suggesting an abnormality in energy metabolism, with an increase in the phosphodiester (PDE) peak. A follow up study 16 months later revealed reduction in size of the lesion on MRI and normal intracellular biochemistry by MRS. Four MS patients without visible superficial cerebral lesions showed no significant changes in phosphorus metabolism.

Type:Article
Title:BIOCHEMICAL-CHANGES WITHIN A MULTIPLE-SCLEROSIS PLAQUE INVIVO
Keywords:P-31 NMR, METABOLISM, BRAIN, SPECTROSCOPY, MRI
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Brain Sciences

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