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CORRELATIONS BETWEEN CHANGES IN DISABILITY AND T-2-WEIGHTED BRAIN MRI ACTIVITY IN MULTIPLE-SCLEROSIS - A FOLLOW-UP-STUDY

FILIPPI, M; PATY, DW; KAPPOS, L; BARKHOF, F; COMPSTON, DAS; THOMPSON, AJ; ZHAO, GJ; ... MILLER, DH; + view all (1995) CORRELATIONS BETWEEN CHANGES IN DISABILITY AND T-2-WEIGHTED BRAIN MRI ACTIVITY IN MULTIPLE-SCLEROSIS - A FOLLOW-UP-STUDY. NEUROLOGY , 45 (2) 255 - 260.

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Abstract

We obtained two conventional unenhanced T-2-weighted brain MRI scans, separated by an interval of 24 to 36 months, in 281 patients with multiple sclerosis (MS). At the time of each scan, clinical disability was rated using the Kurtake Expanded Disability Status Scale (EDSS). Changes in disability between the two examinations correlated weakly but significantly with the number of new (Spearman's rank correlation coefficient = 0.13; p = 0.02) and enlarging (Spearman's rank correlation coefficient = 0.18; p = 0.002) MRI lesions. This result suggests that brain T-2-weighted MRI is a useful supplementary marker of disease activity in definitive (phase III) clinical treatment trials in MS.

Type: Article
Title: CORRELATIONS BETWEEN CHANGES IN DISABILITY AND T-2-WEIGHTED BRAIN MRI ACTIVITY IN MULTIPLE-SCLEROSIS - A FOLLOW-UP-STUDY
Keywords: STATUS SCALE EDSS, RELAPSING PATIENTS, SERIAL, DISEASE, DIAGNOSIS, DYNAMICS, TRIAL
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: http://discovery.ucl.ac.uk/id/eprint/147279
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