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Bile duct-ligated mice exhibit multiple phenotypic similarities to acute decompensation patients despite histological differences

O'Brien, A; China, L; Massey, KA; Nicolaou, A; Winstanley, A; Newson, J; Hobbs, A; ... Gilroy, DW; + view all (2016) Bile duct-ligated mice exhibit multiple phenotypic similarities to acute decompensation patients despite histological differences. Liver International , 36 (6) pp. 837-846. 10.1111/liv.12876. Green open access

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Abstract

Patients with decompensated cirrhosis are susceptible to infection. Innate immune dysfunction and development of organ failure are considered to underlie this. A rodent model of liver disease sharing these phenotypic features would assist in vivo study of underlying mechanisms and testing of therapeutics. We evaluated three models to identify which demonstrated the greatest clinical and immunological phenotypic similarity to patients with acutely decompensated (AD) cirrhosis.

Type: Article
Title: Bile duct-ligated mice exhibit multiple phenotypic similarities to acute decompensation patients despite histological differences
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/liv.12876
Publisher version: http://dx.doi.org/10.1111/liv.12876
Language: English
Additional information: © 2015 The Authors. Liver International Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Bile duct ligation, carbon tetrachloride, eicosanoids, immune suppression, leucocyte trafficking
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Metabolism and Experi Therapeutics
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Nephrology
URI: http://discovery.ucl.ac.uk/id/eprint/1472617
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