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Temporally Dissociable Contributions of Human Medial Prefrontal Subregions to Reward-Guided Learning

Hauser, TU; Hunt, LT; Iannaccone, R; Walitza, S; Brandeis, D; Brem, S; Dolan, RJ; (2015) Temporally Dissociable Contributions of Human Medial Prefrontal Subregions to Reward-Guided Learning. J Neurosci , 35 (32) pp. 11209-11220. 10.1523/JNEUROSCI.0560-15.2015. Green open access

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Abstract

In decision making, dorsal and ventral medial prefrontal cortex show a sensitivity to key decision variables, such as reward prediction errors. It is unclear whether these signals reflect parallel processing of a common synchronous input to both regions, for example from mesocortical dopamine, or separate and consecutive stages in reward processing. These two perspectives make distinct predictions about the relative timing of feedback-related activity in each of these regions, a question we address here. To reconstruct the unique temporal contribution of dorsomedial (dmPFC) and ventromedial prefrontal cortex (vmPFC) to simultaneously measured EEG activity in human subjects, we developed a novel trialwise fMRI-informed EEG analysis that allows dissociating correlated and overlapping sources. We show that vmPFC uniquely contributes a sustained activation profile shortly after outcome presentation, whereas dmPFC contributes a later and more peaked activation pattern. This temporal dissociation is expressed mainly in the alpha band for a vmPFC signal, which contrasts with a theta based dmPFC signal. Thus, our data show reward-related vmPFC and dmPFC responses have distinct time courses and unique spectral profiles, findings that support distinct functional roles in a reward-processing network.

Type: Article
Title: Temporally Dissociable Contributions of Human Medial Prefrontal Subregions to Reward-Guided Learning
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1523/JNEUROSCI.0560-15.2015
Additional information: Copyright © 2015 Hauser, Hunt et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License CreativeCommonsAttribution4.0International, whichpermitsunrestricteduse,distributionandreproductioninany medium provided that the original work is properly attributed
Keywords: activation time-courses, medial prefrontal cortex, reward prediction error, simultaneous EEG-fMRI
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/1472496
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