Mann, CLA and Davies, MB and Stevenson, VL and Leary, SM and Boggild, MD and Ko, CK and Jones, PW and Fryer, AA and Strange, RC and Thompson, AJ and Hawkins, CP (2002) Interleukin 1 genotypes in multiple sclerosis and relationship to disease severity. J NEUROIMMUNOL , 129 (1-2) 197 - 204.
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We studied the association between clinical outcome in MS and allelic variants single nucleotide polymorphisms (SNPs) of interleukin-1alpha (IL-1alpha), IL-1beta and a variable number tandem repeat (VNTR) in IL-1 receptor antagonist (IL-1RN). A total of 377 patients with MS were studied. Significant associations between IL-1 genotypes and clinical outcome were found using logistic regression after correction for gender, onset age and disease duration. The same trends were subsequently demonstrated in a second independent group of 67 primary progressive patients. Our results suggest that genetically determined immunomodulation mediated by IL-1 influences long-term prognosis in multiple sclerosis (MS). (C) 2002 Elsevier Science B.V. All rights reserved.
|Title:||Interleukin 1 genotypes in multiple sclerosis and relationship to disease severity|
|Keywords:||multiple sclerosis, interleukin-1, interleukin-1 receptor antagonist, severity, linkage disequilibrium, SNP, RECEPTOR ANTAGONIST IL-1RA, BLOOD-BRAIN-BARRIER, GENETIC ASSOCIATION, CRYSTAL-STRUCTURE, POLYMORPHISM, MS, MRI, SUSCEPTIBILITY, MARKERS, CLUSTER|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Brain Sciences|
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