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Interleukin 1 genotypes in multiple sclerosis and relationship to disease severity

Mann, CLA; Davies, MB; Stevenson, VL; Leary, SM; Boggild, MD; Ko, CK; Jones, PW; (2002) Interleukin 1 genotypes in multiple sclerosis and relationship to disease severity. J NEUROIMMUNOL , 129 (1-2) 197 - 204.

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Abstract

We studied the association between clinical outcome in MS and allelic variants single nucleotide polymorphisms (SNPs) of interleukin-1alpha (IL-1alpha), IL-1beta and a variable number tandem repeat (VNTR) in IL-1 receptor antagonist (IL-1RN). A total of 377 patients with MS were studied. Significant associations between IL-1 genotypes and clinical outcome were found using logistic regression after correction for gender, onset age and disease duration. The same trends were subsequently demonstrated in a second independent group of 67 primary progressive patients. Our results suggest that genetically determined immunomodulation mediated by IL-1 influences long-term prognosis in multiple sclerosis (MS). (C) 2002 Elsevier Science B.V. All rights reserved.

Type: Article
Title: Interleukin 1 genotypes in multiple sclerosis and relationship to disease severity
Keywords: multiple sclerosis, interleukin-1, interleukin-1 receptor antagonist, severity, linkage disequilibrium, SNP, RECEPTOR ANTAGONIST IL-1RA, BLOOD-BRAIN-BARRIER, GENETIC ASSOCIATION, CRYSTAL-STRUCTURE, POLYMORPHISM, MS, MRI, SUSCEPTIBILITY, MARKERS, CLUSTER
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences
URI: http://discovery.ucl.ac.uk/id/eprint/147243
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