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Real-time dielectrophoretic signaling and image quantification methods for evaluating electrokinetic properties of nanoparticles

Bakewell, DJ; Bailey, J; Holmes, D; (2015) Real-time dielectrophoretic signaling and image quantification methods for evaluating electrokinetic properties of nanoparticles. Electrophoresis , 36 (13) pp. 1443-1450. 10.1002/elps.201400500. Green open access

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Abstract

Real-time image signaling and quantification methods are described that allow easy-to-use, fast extraction of the electrical properties of nanoparticles. Positive dielectrophoretic (pDEP) collection rate analysis enables the dielectric properties of very small samples of nanoparticles to be accurately quantified. Advancing earlier work involving dual-cycle pulsed pDEP [1] collection experiments, we report the development of a statistical image quantification method that significantly advances the evaluation of nanoparticle dielectric properties. Compared with traditional methods that require information about the geometry of the electrode array to be entered for semiautomated quantification [2], the new statistical approach described does not require a priori knowledge of device geometry. The efficacy of the statistical method is experimentally demonstrated using 200 nm diameter latex nanospheres, suspended in low conductivity medium, that are attracted by pDEP onto planar castellated electrode arrays with 5-micron-sized features. The method is shown to yield estimates for the nanoparticle conductivity and surface conductance, inline image mS/m and inline image nS, that concur closely with those obtained using traditional geometric methods previously reported [1]. Consequently, the statistical method is accurate, fast, robust, supervisor-free, and useful for determining nanoparticle electrokinetic parameters.

Type: Article
Title: Real-time dielectrophoretic signaling and image quantification methods for evaluating electrokinetic properties of nanoparticles
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/elps.201400500
Publisher version: http://dx.doi.org/10.1002/elps.201400500
Language: English
Additional information: © 2015 The Authors. ELECTROPHORESIS Published by WILEY-VCH Verlag GmbH & Co. KGaA This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > London Centre for Nanotechnology
URI: http://discovery.ucl.ac.uk/id/eprint/1472213
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