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Processing of Feature Selectivity in Cortical Networks with Specific Connectivity

Sadeh, S; Clopath, C; Rotter, S; (2015) Processing of Feature Selectivity in Cortical Networks with Specific Connectivity. PLoS One , 10 (6) , Article e0127547. 10.1371/journal.pone.0127547. Green open access

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Abstract

Although non-specific at the onset of eye opening, networks in rodent visual cortex attain a non-random structure after eye opening, with a specific bias for connections between neurons of similar preferred orientations. As orientation selectivity is already present at eye opening, it remains unclear how this specificity in network wiring contributes to feature selectivity. Using large-scale inhibition-dominated spiking networks as a model, we show that feature-specific connectivity leads to a linear amplification of feedforward tuning, consistent with recent electrophysiological single-neuron recordings in rodent neocortex. Our results show that optimal amplification is achieved at an intermediate regime of specific connectivity. In this configuration a moderate increase of pairwise correlations is observed, consistent with recent experimental findings. Furthermore, we observed that feature-specific connectivity leads to the emergence of orientation-selective reverberating activity, and entails pattern completion in network responses. Our theoretical analysis provides a mechanistic understanding of subnetworks' responses to visual stimuli, and casts light on the regime of operation of sensory cortices in the presence of specific connectivity.

Type: Article
Title: Processing of Feature Selectivity in Cortical Networks with Specific Connectivity
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0127547
Publisher version: http://dx.doi.org/10.1371/journal.pone.0127547
Additional information: © 2015 Sadeh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1471727
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