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Chronic stress at work and the metabolic syndrome: prospective study

Chandola, T; Brunner, E; Marmot, M; (2006) Chronic stress at work and the metabolic syndrome: prospective study. BRIT MED J , 332 (7540) 521 - 524A. 10.1136/bmj.38693.435301.80. Gold open access

Abstract

Objectives To investigate the association between stress at work and the metabolic syndrome.Design Prospective cohort study investigating the association between work stress and the metabolic syndrome.Participants 10 308 men and women, aged 35-55, employed in 20 London civil service departments at baseline (the Whitehall 11 study); follow-up was an average of 14 years.Main outcome measures Work stress based on the iso-strain model, measured on four occasions (1985-99). Biological measures of the metabolic syndrome, based on the National Cholesterol Education Program definition, measured in 1999.Results A dose-response relation was found between exposure to work stressors over 14 years and risk of the metabolic syndrome, independent of other relevant risk factors. Employees with chronic work stress (three or more exposures) were more than twice as likely to have the syndrome than those without work stress (odds ratio adjusted for age and employment grade 2.25, 95% confidence interval 1.31 to 3.85).Conclusions Stress at work is an important risk factor for the metabolic syndrome. The study provides evidence for the biological plausibility of the link between psychosocial stressors from everyday life and heart disease.

Type: Article
Title: Chronic stress at work and the metabolic syndrome: prospective study
Open access status: An open access publication
DOI: 10.1136/bmj.38693.435301.80
Publisher version: http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC13881...
Keywords: WHITEHALL-II, RISK-FACTORS, CARDIOVASCULAR-DISEASE, BLOOD-PRESSURE, CORONARY RISK, JOB STRAIN, ASSOCIATION, LINK, REWARD, MEN
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: http://discovery.ucl.ac.uk/id/eprint/146993
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