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Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease

Ong, SB; Kalkhoran, SB; Cabrera-Fuentes, HA; Hausenloy, DJ; (2015) Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease. European Journal of Pharmacology , 763 (Part A) pp. 104-114. 10.1016/j.ejphar.2015.04.056. Green open access

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Abstract

The past decade has witnessed a number of exciting developments in the field of mitochondrial dynamics - a phenomenon in which changes in mitochondrial shape and movement impact on cellular physiology and pathology. By undergoing fusion and fission, mitochondria are able to change their morphology between elongated interconnected networks and discrete fragmented structures, respectively. The cardiac mitochondria, in particular, have garnered much interest due to their unique spatial arrangement in the adult cardiomyocyte, and the multiple roles they play in cell death and survival. In this article, we review the role of the mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease.

Type: Article
Title: Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ejphar.2015.04.056
Publisher version: http://dx.doi.org/ 10.1016/j.ejphar.2015.04.056
Additional information: © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Keywords: Calcineurin (PubChem CID:16219117), Chemical compounds studied in this article, Drp1, Dynasore (PubChem CID:5717066), MFN1, MFN2, Mitochondrial fission, Mitochondrial fusion, OPA1, Phenylephrine (PubChem CID:6041), mdivi-1 (PubChem CID:3825829)
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: http://discovery.ucl.ac.uk/id/eprint/1469148
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