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A Multi-Path Approach to Histology Volume Reconstruction

Pichat, J; Modat, M; Yousry, T; Ourselin, S; (2015) A Multi-Path Approach to Histology Volume Reconstruction. In: Angelini, E and Kovačević, J and Ourselin, S and Rittscher, J, (eds.) ISBI 2015: 12th International Symposium on Biomedical Imaging. (pp. pp. 1280-1283). IEEE Green open access

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Abstract

This paper presents a method for correcting erratic pairwise registrations when reconstructing a volume from 2D histology slices. Due to complex and unpredictable alterations of the content of histology images, a pairwise rigid registration between two adjacent slices may fail systematically. Conversely, a neighbouring registration, which potentially involves one of these two slices, will work. This grounds our approach: using correct spatial correspondences established through neighbouring registrations to account for direct failures. We propose to search the best alignment of every couple of adjacent slices from a finite set of transformations that involve neighbouring slices in a transitive fashion. Using the proposed method, we obtained reconstructed volumes with increased coherence compared to the classical pairwise approach, both in synthetic and real data.

Type: Proceedings paper
Title: A Multi-Path Approach to Histology Volume Reconstruction
Event: ISBI 2015: 12th IEEE International Symposium on Biomedical Imaging, 16-19 April 2015, New York, USA
Location: New York, US
Dates: 2015-04-16 - 2015-04-19
ISBN-13: 9781479923748
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/ISBI.2015.7164108
Publisher version: https://doi.org/10.1109/ISBI.2015.7164108
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: volume reconstruction, Rigid registration, histology, Image reconstruction, Biomedical imaging, Three-dimensional displays, Image resolution, Histograms, Nervous system
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1468614
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