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Modelling of Mitochondrial Oxygen Consumption and NIRS Detection of Cytochrome Oxidase Redox State

Banaji, M; Mallet, A; Elwell, CE; Nicholls, P; Tachtsidis, I; Smith, M; Cooper, CE; (2010) Modelling of Mitochondrial Oxygen Consumption and NIRS Detection of Cytochrome Oxidase Redox State. In: Takahashi, E and Bruley, DF, (eds.) Oxygen Transport to Tissue XXXI. (pp. 285 - 291). Springer Verlag: Berlin/ Heidelberg, Germany. Green open access

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Abstract

In recent years there has been widespread use of near infrared spectroscopy (MRS) to monitor the brain. The signals of interest include changes in the levels of oxygenated and deoxygenated haemoglobin and tissue oxygen saturation. In addition to oxy- and deoxy-haemoglobin, the Cu-A centre in cytochrome-c-oxidase (CCO) is a significant NIR absorber, giving rise to another signal termed the Delta oxCCO signal. This signal has great potential as a marker of cellular oxygen metabolism, but is also the hardest to interpret. Here we use a recently constructed model to predict NIRS signal changes, and compare the model output to data from an in vivo hypoxia study in healthy adults. Our findings indicate strongly that the Delta oxCCO signal contains useful information despite the noise, and has responses consistent with the known physiology.

Type: Proceedings paper
Title: Modelling of Mitochondrial Oxygen Consumption and NIRS Detection of Cytochrome Oxidase Redox State
Event: 36th Annual Meeting of the International Society on Oxygen Transport to Tissue (ISOTT)
Location: Sapporo, JAPAN
Dates: 3 - 7 August, 2008
ISBN-13: 9781441912398
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-1-4419-1241-1_41
Publisher version: http://dx.doi.org/10.1007/978-1-4419-1241-1_41
Language: English
Additional information: © 2010 Springer Verlag. The original publication is available at www.springerlink.com
Keywords: NEAR-INFRARED SPECTROSCOPY, OXIDATIVE-PHOSPHORYLATION, CEREBRAL HEMODYNAMICS, LIMITATIONS, ARTERIAL
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/146821
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