UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

A model of brain circulation and metabolism: NIRS signal changes during physiological challenges

Banaji, M; Mallet, A; Elwell, CE; Nicholls, P; Cooper, CE; (2008) A model of brain circulation and metabolism: NIRS signal changes during physiological challenges. PLoS Computational Biology , 4 (11) , Article e1000212. 10.1371/journal.pcbi.1000212. Green open access

[thumbnail of journal.pcbi.1000212.pdf]
Preview
PDF
journal.pcbi.1000212.pdf

Download (630kB)

Abstract

We construct a model of brain circulation and energy metabolism. The model is designed to explain experimental data and predict the response of the circulation and metabolism to a variety of stimuli, in particular, changes in arterial blood pressure, CO2 levels, O2 levels, and functional activation. Significant model outputs are predictions about blood flow, metabolic rate, and quantities measurable noninvasively using near-infrared spectroscopy (NIRS), including cerebral blood volume and oxygenation and the redox state of the CuA centre in cytochrome c oxidase. These quantities are now frequently measured in clinical settings; however the relationship between the measurements and the underlying physiological events is in general complex. We anticipate that the model will play an important role in helping to understand the NIRS signals, in particular, the cytochrome signal, which has been hard to interpret. A range of model simulations are presented, and model outputs are compared to published data obtained from both in vivo and in vitro settings. The comparisons are encouraging, showing that the model is able to reproduce observed behaviour in response to various stimuli.

Type: Article
Title: A model of brain circulation and metabolism: NIRS signal changes during physiological challenges
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pcbi.1000212
Publisher version: http://dx.doi.org/10.1371/journal.pcbi.1000212
Language: English
Additional information: © 2008 Banaji et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Human brain circulation, Mathematical model, Near infrared spectroscopy, Mitochondria, Cytochrome-c-oxidase
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/146803
Downloads since deposit
148Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item