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Fibroblast biology. Development and differentiation of synovial fibroblasts in arthritis.

Edwards, JC; (2000) Fibroblast biology. Development and differentiation of synovial fibroblasts in arthritis. Arthritis Res , 2 (5) 344 - 347. 10.1186/ar110.

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Abstract

Synovial fibroblasts occur as two phenotypes--intimal and subintimal. The specialised intimal phenotype includes expression of uridine diphosphoglucose dehydrogenase (UDPGD), vascular cell adhesion molecule-1 (VCAM-1) and complement decay-accelerating factor (DAF). These gene products contribute to specialised functions relating to tissue movement and leucocyte traffic.

Type:Article
Title:Fibroblast biology. Development and differentiation of synovial fibroblasts in arthritis.
Location:England
DOI:10.1186/ar110
Language:English
Additional information:PMCID: PMC130134
Keywords:Animals, Arthritis, Cell Differentiation, Fibroblasts, Humans, Synovial Membrane
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)

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