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Changes in haemostatic system after application of a tourniquet.

Klenerman, L; Chakrabarti, R; Mackie, I; Brozovic, M; Stirling, Y; (1977) Changes in haemostatic system after application of a tourniquet. Lancet , 1 (8019) pp. 970-972. 10.1016/s0140-6736(77)92276-0.

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Abstract

In 35 patients undergoing routine orthopaedic operations in which occlusive tourniquets were used there was a pronounced rise in fibrinolytic activity in the systemic circulation which lasted for at least 15 minutes after the release of the tourniquet; this response was seen after operations on both arms and legs. In contrast there was no increase in fibrinolytic activity in the systemic circulation associated with venous occlusion. Neither the application of a tourniquet nor venous occlusion resulted in changes in factors V or VIII, fibrinogen, or platelet-count. The application of a completely occlusive tourniquet might be a simple form of prophylaxis against deep-vein thrombosis and would avoid the disadvantages of using heparin.

Type: Article
Title: Changes in haemostatic system after application of a tourniquet.
Location: England
DOI: 10.1016/s0140-6736(77)92276-0
Keywords: Adult, Arm, Female, Fibrinolysis, Hemostasis, Surgical, Humans, Leg, Male, Middle Aged, Postoperative Complications, Thrombophlebitis, Tourniquets, Varicose Veins
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/1466883
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