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Patchy expression of lactase protein in adult rabbit and rat intestine.

Maiuri, L; Rossi, M; Raia, V; D'Auria, S; Swallow, D; Quaroni, A; Auricchio, S; (1992) Patchy expression of lactase protein in adult rabbit and rat intestine. Gastroenterology , 103 (6) pp. 1739-1746.

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Abstract

Enzymatic and immunohistological analyses of lactase were performed at different stages of development and within different regions of the small intestine of the rabbit and rat. As previously reported, there seems to be a sharp decline of lactase activity on weaning but variable and higher levels of activity are seen in adult animals. Two monoclonal antibodies to rat lactase were available to study the protein in rats. Four monoclonal antibodies to human lactase were shown to cross-react with rabbit lactase and used for the rabbit studies. Immunohistological analysis of small intestine of adult rabbits and rats showed residual lactase protein within the enterocytes throughout the small intestine. In the middle of the small intestine (lower jejunum, upper ileum), uniform staining of the brush border was observed. In the proximal and distal regions, a patchy pattern of staining was observed. This pattern, which resembles that observed in adult hypolactasic humans, indicates an underlying heterogeneity of enterocyte differentiation.

Type: Article
Title: Patchy expression of lactase protein in adult rabbit and rat intestine.
Location: United States
Keywords: Age Factors, Amino Acid Sequence, Animals, Antibodies, Monoclonal, Humans, Intestines, Lactase, Molecular Sequence Data, Rabbits, Rats, Rats, Wistar, Sucrase, beta-Galactosidase
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: http://discovery.ucl.ac.uk/id/eprint/1465617
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