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Nrf2 regulates ROS production by mitochondria and NADPH oxidase.

Kovac, S; Angelova, PR; Holmström, KM; Zhang, Y; Dinkova-Kostova, AT; Abramov, AY; (2015) Nrf2 regulates ROS production by mitochondria and NADPH oxidase. Biochim Biophys Acta , 1850 (4) 794 - 801. 10.1016/j.bbagen.2014.11.021. Green open access

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Abstract

Nuclear factor (erythroid-derived 2) factor 2 (Nrf2) is a crucial transcription factor mediating protection against oxidants. Nrf2 is negatively regulated by cytoplasmic Kelch-like ECH associated protein 1 (Keap1) thereby providing inducible antioxidant defence. Antioxidant properties of Nrf2 are thought to be mainly exerted by stimulating transcription of antioxidant proteins, whereas its effects on ROS production within the cell are uncertain.

Type: Article
Title: Nrf2 regulates ROS production by mitochondria and NADPH oxidase.
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bbagen.2014.11.021
Publisher version: http://dx.doi.org/10.1016/j.bbagen.2014.11.021
Language: English
Additional information: © 2014 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Keap1, NADPH oxidase, NOX, Nrf2, ROS
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/1465506
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