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New horizons for lipoprotein receptors: communication by β-propellers.

Andersen, OM; Dagil, R; Kragelund, BB; (2013) New horizons for lipoprotein receptors: communication by β-propellers. J Lipid Res , 54 (10) pp. 2763-2774. 10.1194/jlr.M039545.

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Abstract

The lipoprotein receptor (LR) family constitutes a large group of structurally closely related receptors with broad ligand-binding specificity. Traditionally, ligand binding to LRs has been anticipated to involve merely the complement type repeat (CR)-domains omnipresent in the family. Recently, this dogma has transformed with the observation that β-propellers of some LRs actively engage in complex formation too. Based on an in-depth decomposition of current structures and sequences, we suggest that exploitation of the β-propellers as binding targets depends on receptor subgroups. In particular, we highlight the shutter mechanism of β-propellers as a general recognition motif for NxI-containing ligands, and we present indications that the generalized β-propeller-induced ligand release mechanism is not applicable for the larger LRs. For the giant LR members, we present evidence that their β-propellers may also actively engage in ligand binding. We therefore advocate for an increased focus on solving the structure-function relationship of this group of important biological receptors.

Type: Article
Title: New horizons for lipoprotein receptors: communication by β-propellers.
Location: United States
DOI: 10.1194/jlr.M039545
Keywords: Tyr-Trp-Thr-Asp β-propeller, endocytosis, internalisation, ligand recognition motif, ligand release, structure, Amino Acid Sequence, Humans, Hydrogen-Ion Concentration, Models, Molecular, Molecular Sequence Data, Protein Interaction Domains and Motifs, Protein Structure, Secondary, Receptors, Lipoprotein, Sequence Homology, Amino Acid, Signal Transduction, Structural Homology, Protein
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1465287
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