Mocroft, A; Lundgren, JD; Ross, M; Law, M; Reiss, P; Kirk, O; Smith, C; ... ESPRIT study group, .; + view all Mocroft, A; Lundgren, JD; Ross, M; Law, M; Reiss, P; Kirk, O; Smith, C; Wentworth, D; Neuhaus, J; Fux, CA; Moranne, O; Morlat, P; Johnson, MA; Ryom, L; D:A:D study group, .; Royal Free Hospital Clinic Cohort, .; INSIGHT study group, .; SMART study group, .; ESPRIT study group, .; - view fewer (2015) Development and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study. PLoS Med , 12 (3) , Article e1001809 . 10.1371/journal.pmed.1001809.

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Abstract

Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice.

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