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Genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice

Krohn, J; Speed, D; Palme, R; Touma, C; Mott, R; Flint, J; (2014) Genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice. PLOS One , 9 (5) , Article e96450. 10.1371/journal.pone.0096450. Green open access

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Abstract

The extent to which sex-specific genetic effects contribute to phenotypic variation is largely unknown. We applied a novel Bayesian method, sparse partitioning, to detect gene by sex (GxS) and gene by gene (GxG) quantitative loci (QTLs) in 1,900 outbred heterogeneous stock mice. In an analysis of 55 phenotypes, we detected 16 GxS and 6 GxG QTLs. The increase in the amount of phenotypic variance explained by models including GxS was small, ranging from 0.14% to 4.30%. We conclude that GxS rarely make a large overall contribution to the heritability of phenotypes, however there are cases where these will be individually important.

Type: Article
Title: Genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0096450
Publisher version: http://dx.doi.org/10.1371/journal.pone.0096450
Language: English
Additional information: Copyright © 2014 Krohn et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Animals, Bayes Theorem, Chromosome Mapping, Female, Genetic Variation, Male, Mice, Phenotype, Quantitative Trait Loci, Quantitative Trait, Heritable, Sex Factors
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery.ucl.ac.uk/id/eprint/1462325
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