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Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis.

Rohrer, JD; Nicholas, JM; Cash, DM; van Swieten, J; Dopper, E; Jiskoot, L; van Minkelen, R; ... Rossor, MN; + view all (2015) Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis. Lancet Neurol , 14 (3) 253 - 262. 10.1016/S1474-4422(14)70324-2. Green open access

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Abstract

Frontotemporal dementia is a highly heritable neurodegenerative disorder. In about a third of patients, the disease is caused by autosomal dominant genetic mutations usually in one of three genes: progranulin (GRN), microtubule-associated protein tau (MAPT), or chromosome 9 open reading frame 72 (C9orf72). Findings from studies of other genetic dementias have shown neuroimaging and cognitive changes before symptoms onset, and we aimed to identify whether such changes could be shown in frontotemporal dementia.

Type: Article
Title: Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/S1474-4422(14)70324-2
Publisher version: http://dx.doi.org/10.1016/S1474-4422(14)70324-2
Language: English
Additional information: © Rohrer et al. Open Access article distributed under the terms of CC BY.
URI: http://discovery.ucl.ac.uk/id/eprint/1462283
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