Zhang, L;
Tang, F;
Terracciano, L;
Hynx, D;
Kohler, R;
Bichet, S;
Hess, D;
... Schmitz-Rohmer, D; + view all
(2015)
NDR functions as a physiological YAP1 kinase in the intestinal epithelium.
Current Biology
, 25
(3)
296 - 305.
10.1016/j.cub.2014.11.054.
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Abstract
Phosphorylation of the transcriptional coactivator YAP1 is a key event in defining Hippo signaling outputs. Previous studies demonstrated that phosphorylation of YAP1 at serine 127 (S127) sequesters YAP1 in the cytoplasm and consequently inhibits YAP1 transcriptional activity. Mammalian tissue-culture experiments suggest that downstream of MST1/2 signaling, LATS1/2 function as YAP1-S127 kinases. However, studies of Mst1/2 knockout mouse models revealed that the identity of the physiological YAP1-S127 kinase(s) in certain tissues, such as the intestine, remains unknown.
| Type: | Article |
|---|---|
| Title: | NDR functions as a physiological YAP1 kinase in the intestinal epithelium. |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.cub.2014.11.054 |
| Publisher version: | http://dx.doi.org/10.1016/j.cub.2014.11.054 |
| Language: | English |
| Additional information: | This article is published under a Creative Commons Attribution 4.0 International license (CC BY 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1461434 |
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