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PLA2G10 Gene Variants, sPLA2 Activity, and Coronary Heart Disease Risk.

Guardiola, M; Exeter, HJ; Perret, C; Folkersen, L; Van't Hooft, F; Eriksson, P; Franco-Cereceda, A; ... Talmud, PJ; + view all (2015) PLA2G10 Gene Variants, sPLA2 Activity, and Coronary Heart Disease Risk. Circ Cardiovasc Genet , 8 (2) 356 - 362. 10.1161/CIRCGENETICS.114.000633. Green open access

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Abstract

Observational studies report that secretory phospholipase A2 (sPLA2) activity is a marker for coronary heart disease (CHD) risk, and activity measures are thought to represent the composite activity of sPLA2-IIA, -V, and -X. The aim of this study was to use genetic variants of PLA2G10, encoding sPLA2-X, to investigate the contribution of sPLA2-X to the measure of sPLA2 activity and coronary heart disease (CHD) risk traits and outcome.

Type: Article
Title: PLA2G10 Gene Variants, sPLA2 Activity, and Coronary Heart Disease Risk.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1161/CIRCGENETICS.114.000633
Publisher version: http://dx.doi.org/10.1161/CIRCGENETICS.114.000633
Language: English
Additional information: © 2015 American Heart Association, Inc.
Keywords: PLA2G10, genetic polymorphism
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Centre for Cardiovascular Genetics
URI: http://discovery.ucl.ac.uk/id/eprint/1461268
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