Aldridge, RW;
Mattes, FM;
Rolando, N;
Rolles, K;
Smith, C;
Shirling, G;
Atkinson, C;
... Griffiths, PD; + view all
(2015)
Effects of donor/recipient human leukocyte antigen mismatch on human cytomegalovirus replication following liver transplantation.
Transplant Infectious Disease
, 17
(1)
25 - 32.
10.1111/tid.12325.
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Abstract
Natural immunity against cytomegalovirus (CMV) can control virus replication after solid organ transplantation; however, it is not known which components of the adaptive immune system mediate this protection. We investigated whether this protection requires human leukocyte antigen (HLA) matching between donor and recipient by exploiting the fact that, unlike transplantation of other solid organs, liver transplantation does not require HLA matching, but some donor and recipient pairs may nevertheless be matched by chance.
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