UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Analysis of the procoagulant activities of factor IX concentrates.

Mackie, IJ; Seghatchian, MJ; (1982) Analysis of the procoagulant activities of factor IX concentrates. Thromb Res , 28 (4) pp. 499-507.

Full text not available from this repository.

Abstract

The Factor VIII content of Factor IX concentrates was investigated by agarose gel electrophoresis which removed the interfering effects of stabilisers and proteolytic enzyme inhibitors. Factor VIII coagulant activity (FVIII C) as measured by clotting and amidolytic methods correlated well with the distribution of FVIII coagulant antigen (FVIII CAg). The FVIIIC activity was apparently not entirely due to the presence of activated coagulation enzymes, since none of the enzymicity patterns observed with various chromogenic substrates correlated completely with the FVIII peak. However, some enzyme activity was detected in positions coincident with the margins of the FVIII peak; these activities may represent complexes of some of the FVIII with activated coagulation factors.

Type: Article
Title: Analysis of the procoagulant activities of factor IX concentrates.
Location: United States
Keywords: Antigens, Blood Coagulation, Factor IX, Factor IXa, Factor VIII, Humans, Oligopeptides, Thrombin Time, von Willebrand Factor
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/1458736
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item