UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Molecular genetic characterisation of frontotemporal dementia on chromosome 3

Ashworth, A; Lloyd, S; Brown, J; Gydesen, S; Sorensen, SA; Brun, A; Englund, E; ... Collinge, J; + view all (1999) Molecular genetic characterisation of frontotemporal dementia on chromosome 3. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS , 10 93 - 101.

Full text not available from this repository.

Abstract

We have previously localized a locus causing familial nonspecific dementia to the centromeric region of chromosome 3 in a pedigree from the Jutland area of Denmark. Th is pedigree shows anticipation. Here we present further analysis of these anticipation data which are suggestive of trinucleotide repeat expansion involvement. We also outline our strategies to clone the mutant gene via its putative associated trinucleotide repeat sequence.

Type: Article
Title: Molecular genetic characterisation of frontotemporal dementia on chromosome 3
Location: LUND, SWEDEN
Keywords: frontal robe dementia, familial nonspecific dementia, anticipation, trinucleotide repeat, DOMINANT CEREBELLAR-ATAXIA, REPEAT EXPANSION DETECTION, NEURONAL INTRANUCLEAR INCLUSIONS, MULTIPLE-SYSTEM TAUOPATHY, PRESENILE-DEMENTIA, POLYGLUTAMINE EXPANSIONS, TRINUCLEOTIDE REPEATS, HUNTINGTON DISEASE, FRONTAL-LOBE, HUMAN GENOME
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Neurodegenerative Diseases
URI: http://discovery.ucl.ac.uk/id/eprint/145851
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item