UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Predonation Health-Related Quality of Life Scores Predict Time to Recovery in Hematopoietic Stem Cell Donors

Billen, A; Madrigal, JA; Strydom, A; Szydlo, RM; Switzer, GE; Shaw, BE; (2015) Predonation Health-Related Quality of Life Scores Predict Time to Recovery in Hematopoietic Stem Cell Donors. Biology of Blood and Marrow Transplantation , 21 (2) pp. 350-356. 10.1016/j.bbmt.2014.10.028. Green open access

[img]
Preview
Text
Strydom_1-s2.0-S1083879114006673-main.pdf

Download (802kB) | Preview

Abstract

The physical reactions to hematopoietic stem cell donation have been extensively studied, but less is known about factors that predict poorer donation experiences. The aim of this prospective study was to examine demographic and health-related quality of life (HRQOL) factors that might be associated with recovery and side effects. We also described the changes in HRQOL during the donation process. In total, 275 peripheral blood stem cell (PBSC) and 37 bone marrow (BM) consecutive donors completed the SF-36 questionnaire predonation and 4 weeks, and 3 months postdonation. Predonation HRQOL markers were the strongest predictors of time to recovery. Poorer predonation physical health was associated with longer recovery (P = .017) and certain side effects in PBSC donors. Poorer predonation mental health was associated with longer recovery in BM donors (P = .03) and pain after PBSC donation (P = .003). Physical HRQOL scores declined significantly from predonation to 4 weeks postdonation. This was shown both for PBSC and BM donors (P < .001 and P = .009, respectively), but the decline was much greater for BM donors. There was a return to predonation HRQOL values 3 months after donation in both groups with values well above the mean of the general population (P < .001).

Type: Article
Title: Predonation Health-Related Quality of Life Scores Predict Time to Recovery in Hematopoietic Stem Cell Donors
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bbmt.2014.10.028
Publisher version: http://dx.doi.org/10.1016/j.bbmt.2014.10.028
Language: English
Additional information: Copyright © 2015 American Society for Blood and Marrow Transplantation. This is an Open Access article published under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Bone marrow, Donation experience, Health-related quality of life, Peripheral blood stem cells, Adolescent, Adult, Bone Marrow Transplantation, Convalescence, Female, Hematopoietic Stem Cell Mobilization, Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cells, Humans, Male, Mental Health, Middle Aged, Pain, Peripheral Blood Stem Cell Transplantation, Prospective Studies, Quality of Life, Research Design, Surveys and Questionnaires, Time Factors, Tissue Donors
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/1458504
Downloads since deposit
80Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item