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Do opioid peptides mediate a presynaptic control of C-fibre transmission in the rat spinal cord?

Woolf, CJ; Fitzgerald, M; (1982) Do opioid peptides mediate a presynaptic control of C-fibre transmission in the rat spinal cord? Neurosci Lett , 29 (1) pp. 67-72.

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Abstract

A presynaptic inhibitory role for opioid peptides in the control of C-fibre-evoked activity in the dorsal horn has been investigated. The excitability of C-fibre terminals in the dorsal horn of decerebrate spinal rats was tested using intraspinal terminal stimulation and recording the size of the antidromic C wave from the dorsal roots. Naloxone (1-2 mg/kg) failed to alter the baseline terminal excitability of the C-fibres, but reduced the increase in terminal excitability produced by A-fibre afferent conditioning stimuli. The inhibition of postsynaptic C-evoked activity in lamina 5 cells produced by A-afferent fibre conditioning stimuli was also reduced by naloxone. This effect may reflect the reversal of an opioid-mediated presynaptic inhibition, although blockade of a direct postsynaptic inhibitory action could also be involved.

Type: Article
Title: Do opioid peptides mediate a presynaptic control of C-fibre transmission in the rat spinal cord?
Location: Ireland
Keywords: Animals, Differential Threshold, Endorphins, Evoked Potentials, Naloxone, Nerve Endings, Nerve Fibers, Rats, Spinal Cord, Substantia Gelatinosa, Synapses, Synaptic Transmission
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/1458349
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