Peng, X;
Alföldi, J;
Gori, K;
Eisfeld, AJ;
Tyler, SR;
Tisoncik-Go, J;
Brawand, D;
... Katze, MG; + view all
(2014)
The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease.
[Letter].
Nature Biotechnology
, 32
(12)
pp. 1250-1255.
10.1038/nbt.3079.
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Abstract
The domestic ferret (Mustela putorius furo) is an important animal model for multiple human respiratory diseases. It is considered the 'gold standard' for modeling human influenza virus infection and transmission. Here we describe the 2.41 Gb draft genome assembly of the domestic ferret, constituting 2.28 Gb of sequence plus gaps. We annotated 19,910 protein-coding genes on this assembly using RNA-seq data from 21 ferret tissues. We characterized the ferret host response to two influenza virus infections by RNA-seq analysis of 42 ferret samples from influenza time-course data and showed distinct signatures in ferret trachea and lung tissues specific to 1918 or 2009 human pandemic influenza virus infections. Using microarray data from 16 ferret samples reflecting cystic fibrosis disease progression, we showed that transcriptional changes in the CFTR-knockout ferret lung reflect pathways of early disease that cannot be readily studied in human infants with cystic fibrosis disease.
| Type: | Article |
|---|---|
| Title: | The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease. |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/nbt.3079 |
| Publisher version: | http://dx.doi.org/10.1038/nbt.3079 |
| Language: | English |
| Additional information: | This article is distributed under the terms of the Creative Commons Attribution-Non-Commercial-Share Alike license (http://creativecommons.org/licenses/by-nc-sa/3.0/), which permits distribution, and reproduction in any medium, provided the original author and source are credited. This license does not permit commercial exploitation, and derivative works must be licensed under the same or similar license. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1457207 |
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