Bann, DA;
Holly, JMP;
Lashen, H;
Hardy, R;
Adams, J;
Kuh, D;
Ong, KK;
(2015)
Changes in insulin-like growth factor-I and -II associated with fat but not lean mass in early old age.
Obesity
, 23
(3)
pp. 692-698.
10.1002/oby.21002.
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Abstract
Objective To test the hypothesis that insulin-like growth factor-I (IGF-I) and IGF-II decline during late midlife, and greater declines are related to higher fat mass and lower lean mass. Methods 1542 men and women in a British birth cohort study had IGF-I and II measured by immunoassay of blood samples at 53 and/or 60-64y. Fat mass, android: gynoid fat ratio, and appendicular lean mass were measured at 60-64y using dual energy X-ray absorptiometry (DXA). Associations between changes in IGF-I or II and body composition outcomes were examined using conditional change linear regression models. Results Mean IGF-I and IGF-II concentrations were lower at 60-64 than at 53y, by 12.8% for IGF-I and by 12.5% for IGF-II. Larger declines in either IGF-I or II were associated with higher fat mass at 60-64 years. Although higher IGF-I at 53 was associated with higher lean mass, there was little evidence linking changes in IGF-I or II to lean mass. Conclusions Our findings suggest that IGF-I and II concentrations decline with age, and greater declines are associated with higher fat mass levels. These results provide some evidence for the suggested roles of IGF-I and II in regulating fat mass but not lean mass in older age.
| Type: | Article |
|---|---|
| Title: | Changes in insulin-like growth factor-I and -II associated with fat but not lean mass in early old age |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/oby.21002 |
| Publisher version: | http://dx.doi.org/10.1002/oby.21002 |
| Language: | English |
| Additional information: | © 2015 The Authors Obesity published by Wiley Periodicals, Inc. on behalf of The Obesity Society (TOS) This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | insulin-like growth factor I, insulin-like growth factor II, body composition, obesity, skeletal muscle |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Education UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education > IOE - Social Research Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1456627 |
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