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Measurement Bias in Activation-Recovery Intervals from Unipolar Electrograms

Western, DG; Hanson, B; Taggart, P; (2014) Measurement Bias in Activation-Recovery Intervals from Unipolar Electrograms. AJP: Heart and Circulatory Physiology , 308 (4) H331-H338. 10.1152/ajpheart.00478.2014. Green open access

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Abstract

The activation-recovery interval (ARI) calculated from unipolar electrograms is regularly used as a convenient surrogate measure of local cardiac action potential durations (APD). This method enables important research bridging between computational studies, in-vitro and in-vivo human studies. The Wyatt method is well-established as a theoretically sound method for calculating ARIs; however, some studies have observed that it is prone to a bias error in measurement when applied to positive T-waves. This paper demonstrates that recent theoretical and computational studies supporting the use of the Wyatt method are likely to have underestimated the extent of this bias in many practical experimental recording scenarios. This work addresses these situations, and explains the measurement bias by adapting existing theoretical expressions of the electrogram to represent practical experimental recording configurations. A new analytic expression for the electrogram's local component is derived, which identifies the source of measurement bias for positive T-waves. A computer implementation of the new analytic model confirms our hypothesis that the bias is systematically dependent on the electrode configuration. These results provide an aid to electrogram interpretation in general, and this work's outcomes are used to make recommendations on how to minimise measurement error.

Type: Article
Title: Measurement Bias in Activation-Recovery Intervals from Unipolar Electrograms
Open access status: An open access version is available from UCL Discovery
DOI: 10.1152/ajpheart.00478.2014
Publisher version: http://dx.doi.org/10.1152/ajpheart.00478.2014
Language: English
Additional information: Copyright © 2015 the American Physiological Society Licensed under Creative Commons Attribution CC-BY 3.0: © the American Physiological Society.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Clinical Science
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: http://discovery.ucl.ac.uk/id/eprint/1456307
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