The estimation of local brain temperature by in vivo 1H magnetic resonance spectroscopy.
Magn Reson Med
862 - 867.
Brain temperature may be important for investigating pathology and cerebroprotective effects of pharmaceuticals and hypothermia. Two methods for estimating temperature using 1H magnetic resonance spectroscopy are described: a partially water-suppressed binomial sequence and non-water-suppressed point-resolved spectroscopy. Relative to N-acetylaspartate (Naa), water chemical shift (delta H2O-Naa) in piglet brain depended linearly on temperature from 30 degrees to 40 degrees C: temperature was 286.9-94.0 delta H2O-Naa degrees C. Thalamic temperature in six normal infants was 38.1 degrees +/- 0.4 degree C indicating that local brain temperature could be estimated with adequate sensitivity for studying pathologic and therapeutic changes.
|Title:||The estimation of local brain temperature by in vivo 1H magnetic resonance spectroscopy.|
|Keywords:||Animals, Animals, Newborn, Aspartic Acid, Body Temperature, Brain, Brain Chemistry, Humans, Hydrogen-Ion Concentration, Infant, Newborn, Magnetic Resonance Spectroscopy, Swine|
|UCL classification:||UCL > School of BEAMS > Faculty of Engineering Science > Medical Physics and Bioengineering|
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