The estimation of local brain temperature by in vivo 1H magnetic resonance spectroscopy.
Magn Reson Med
Brain temperature may be important for investigating pathology and cerebroprotective effects of pharmaceuticals and hypothermia. Two methods for estimating temperature using 1H magnetic resonance spectroscopy are described: a partially water-suppressed binomial sequence and non-water-suppressed point-resolved spectroscopy. Relative to N-acetylaspartate (Naa), water chemical shift (delta H2O-Naa) in piglet brain depended linearly on temperature from 30 degrees to 40 degrees C: temperature was 286.9-94.0 delta H2O-Naa degrees C. Thalamic temperature in six normal infants was 38.1 degrees +/- 0.4 degree C indicating that local brain temperature could be estimated with adequate sensitivity for studying pathologic and therapeutic changes.
|Title:||The estimation of local brain temperature by in vivo 1H magnetic resonance spectroscopy.|
|Keywords:||Animals, Animals, Newborn, Aspartic Acid, Body Temperature, Brain, Brain Chemistry, Humans, Hydrogen-Ion Concentration, Infant, Newborn, Magnetic Resonance Spectroscopy, Swine|
|UCL classification:||UCL > School of BEAMS > Faculty of Engineering Science
UCL > School of BEAMS > Faculty of Engineering Science > Medical Physics and Bioengineering
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