Quantitative combined phosphorus and proton PRESS of the brains of newborn human infants.
Magn Reson Med
Techniques for quantitative, combined phosphorus and proton, point-resolved spectroscopy (PRESS) studies of newborn-infant brain have been developed. Phosphorus PRESS advantages include: voxel-shimming; rapid transmitter-pulse setting; novel use of brain-water as a localized quantitation reference; and reduced broad components. Proton spectra from 1-ml voxels and phosphorus spectra can both be acquired quantitatively within acceptable time. Cerebral lactate was consistently detected by proton PRESS and the normal concentration (approximately 3 mmol/kg wet weight) may be higher than in adult brain. Phosphorus PRESS provided metabolite peak-area ratios and concentrations comparable with those obtained using ISIS.
|Title:||Quantitative combined phosphorus and proton PRESS of the brains of newborn human infants.|
|Keywords:||Brain, Brain Chemistry, Humans, Infant, Newborn, Lactates, Lactic Acid, Magnetic Resonance Spectroscopy, Phosphorus Isotopes|
|UCL classification:||UCL > School of BEAMS > Faculty of Engineering Science
UCL > School of BEAMS > Faculty of Engineering Science > Medical Physics and Bioengineering
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