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'Skeletal muscle function deficit' in a nationally representative British birth cohort in early old age

Cooper, R; Bann, DA; Wloch, EG; Adams, JE; Kuh, D; (2015) 'Skeletal muscle function deficit' in a nationally representative British birth cohort in early old age. Journal of Gerontology Series A: Biological Sciences and Medical Sciences , 70 (5) pp. 604-607. 10.1093/gerona/glu214. Green open access

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Abstract

BACKGROUND: Recommendations for identifying age-related muscle dysfunction have recently been published. We aimed to compare definitions for clinically relevant weakness and low lean mass proposed by the Foundation for the National Institutes of Health (FNIH) Sarcopenia project with the definition of sarcopenia proposed by the European Working Group on Sarcopenia in Older People (EWGSOP). METHODS: 1566 men and women from a British birth cohort had measures of appendicular lean mass, grip strength and timed up and go speed at ages 60–64. Prevalence of low lean mass, weakness and slowness, identified using the FNIH and EWGSOP recommendations were estimated and compared: using kappa statistics and; by testing cross-sectional associations of both definitions of low lean mass and weakness with slowness and self-reported difficulties walking. RESULTS: The combined prevalence of low lean mass and weakness ranged from 1.1% in men using FNIH criteria to 6.4% in women using EWGSOP criteria. There was limited overlap between the groups identified using the different criteria, driven by limited agreement between the two definitions of low lean mass. Using FNIH criteria, both low lean mass and weakness were associated with higher odds of slowness and difficulties walking whereas low lean mass classified using EWGSOP criteria was not associated with these markers of mobility impairment. CONCLUSIONS: At relatively young ages, signs of skeletal muscle function deficit with potential clinical relevance are already identifiable in the general population. This suggests that implementation of strategies to prevent mobility limitations, related to age-related muscle dysfunction, may need to start at least as early as midlife.

Type: Article
Title: 'Skeletal muscle function deficit' in a nationally representative British birth cohort in early old age
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/gerona/glu214
Publisher version: http://dx.doi.org/10.1093/gerona/glu214
Language: English
Additional information: Copyright © The Author 2014. Published by Oxford University Press on behalf of the Gerontological Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Epidemiology, Life course, Physical capability
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Education
UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education
UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education > IOE - Social Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health
URI: http://discovery.ucl.ac.uk/id/eprint/1455630
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