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Organ pathology following mild hypothermia used as neural rescue therapy in newborn piglets

Amess, PN; Penrice, J; Howard, S; Thoresen, M; Edwards, AD; Cady, EB; Wyatt, JS; (1998) Organ pathology following mild hypothermia used as neural rescue therapy in newborn piglets. BIOL NEONATE , 73 (1) 40 - 46.

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Abstract

The aim of this study was to assess the possible adverse effects of hypothermia, used as neural rescue therapy in a neu born piglet model, Sixteen newborn piglets were subjected to transient cerebral hypoxia-ischaemia by temporary occlusion of the carotid arteries and reduction of the fractional inspired oxygen to 0.12. On resuscitation 11 piglets were maintained normothermic (38.5-39.0 degrees C) and, in order to assess the cerebroprotective effect of hypothermia, 5 piglets were cooled to 35 degrees C for 12 h before normothermia was resumed, At 48 or 64 h following resuscitation the animals were sacrificed and the heart, left kidney, specimens of distal small bowel, lung and liver were removed and histologically sectioned, No microscopic abnormalities of the heart, bowel or lung were observed in hypothermic or normothermic animals. Al kidney specimens were normal except one from the normothermic group, Abnormal liver pathology suggestive of hypoperfusion injury was found in 5 normothermic and 3 hypothermic piglets, Then was no significant difference in the proportion of piglets with liver abnormality between the two groups. Mild hypothermia following cerebral hypoxia-ischaemia in the newborn piglet was not associated with an increased incidence of non-cerebral organ damage, The hepatic injury observed may be related to umbilical venous catheterisation and has potential relevance to neonatal intensive care.

Type: Article
Title: Organ pathology following mild hypothermia used as neural rescue therapy in newborn piglets
Keywords: piglet, hypoxia-ischaemia, hypothermia, histopathology, MAGNETIC-RESONANCE SPECTROSCOPY, CEREBRAL ENERGY FAILURE, ISCHEMIC BRAIN INJURY, HYPOXIA-ISCHEMIA, INFANTS, TEMPERATURE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: http://discovery.ucl.ac.uk/id/eprint/145476
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