UCL Discovery

Abstract

Cerebral apparent diffusion coefficients (ADCs) were determined in nine newborn piglets before and for 48 h after transient hypoxia-ischemia. Phosphorus MRS revealed severely reduced cerebral energy metabolism during the insult and an apparently complete recovery 2 h after resuscitation commenced. At this time, mean ADC over the imaging slice (ADC(global)) was 0.88 (0.04) x 10(-9) m(2) . s(-1) (mean (SD)), which was close to the baseline value of 0.92 (0.4) x 10(-9) m(2) . s(-1). In seven of the animals, a "secondary" failure of energy metabolism then evolved, accompanied by a decline in ADC(global) to 0.64 (0.17) x 10(-9) m(2) . s(-1) at 46 h postresuscitation (P < 0.001 versus baseline). For these seven animals, ADC(global) correlated linearly with the concentration ratio [phosphocreatine (PCr)]/[inorganic phosphate (Pi)] (0.94 < r < 0.99; P < 0.001). A nonlinear relationship was demonstrated between ADC(global) and the concentration ratio [nucleotide triphosphate (NTP)]/ [Pi + PCr + 3 NTP]. The ADC reduction commenced in the parasagittal cortex before spreading in a characteristic pattern throughout the brain. ADC seems to be closely related to cerebral energy status and shows considerable potential for the assessment of hypoxic-ischemic injury in the newborn brain.