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Purinergic signalling and immune cells.

Burnstock, G; Boeynaems, JM; (2014) Purinergic signalling and immune cells. Purinergic Signal , 10 (4) 529 - 564. 10.1007/s11302-014-9427-2. Green open access

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Abstract

This review article provides a historical perspective on the role of purinergic signalling in the regulation of various subsets of immune cells from early discoveries to current understanding. It is now recognised that adenosine 5'-triphosphate (ATP) and other nucleotides are released from cells following stress or injury. They can act on virtually all subsets of immune cells through a spectrum of P2X ligand-gated ion channels and G protein-coupled P2Y receptors. Furthermore, ATP is rapidly degraded into adenosine by ectonucleotidases such as CD39 and CD73, and adenosine exerts additional regulatory effects through its own receptors. The resulting effect ranges from stimulation to tolerance depending on the amount and time courses of nucleotides released, and the balance between ATP and adenosine. This review identifies the various receptors involved in the different subsets of immune cells and their effects on the function of these cells.

Type: Article
Title: Purinergic signalling and immune cells.
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s11302-014-9427-2
Publisher version: http://dx.doi.org/10.1007/s11302-014-9427-2
Language: English
Additional information: © The Author(s) 2014 This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: https://discovery.ucl.ac.uk/id/eprint/1453973
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