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Activity-dependent modulation of synaptic AMPA receptor accumulation

O'Brien, RJ; Kamboj, S; Ehlers, MD; Rosen, KR; Fischbach, GD; Huganir, RL; (1998) Activity-dependent modulation of synaptic AMPA receptor accumulation. NEURON , 21 (5) 1067 - 1078.

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Abstract

Both theoretical and experimental work have suggested that central neurons compensate for changes in excitatory synaptic input in order to maintain a relatively constant output. We report here that inhibition of excitatory synaptic transmission in cultured spinal neurons leads to an increase in mEPSC amplitudes, accompanied by an equivalent increase in the accumulation of AMPA receptors at synapses. Conversely, increasing excitatory synaptic activity leads to a decrease in synaptic AMPA receptors and a decline in mEPSC amplitude. The time course of this synaptic remodeling is slow, similar to the metabolic half-life of neuronal AMPA receptors. Moreover, inhibiting excitatory synaptic transmission significantly prolongs the half-life, of the AMPA receptor subunit GluR1, suggesting that synaptic activity modulates the size of the mEPSC by regulating the turnover of postsynaptic AMPA receptors.

Type: Article
Title: Activity-dependent modulation of synaptic AMPA receptor accumulation
Keywords: HIPPOCAMPAL-NEURONS, GLUTAMATE-RECEPTOR, ACETYLCHOLINE-RECEPTORS, NMDA RECEPTOR, TRANSMISSION, SYNAPSES, CULTURE, SUBUNIT
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: http://discovery.ucl.ac.uk/id/eprint/145074
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